Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Selection bias in case-control studies using relatives as the controls.

A M Goldstein¹, S E Hodge, R W Haile

¹Division of Epidemiology, UCLA School of Public Health 90024.

International Journal of Epidemiology

|December 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.

Genetics in medicine : official journal of the American College of Medical Genetics·2021

Same author

Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity.

The British journal of dermatology·2020

Same author

Guidelines for the management of postoperative soiling in children with Hirschsprung disease.

Pediatric surgery international·2019

Same author

Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Same author

International cancer seminars: a focus on esophageal squamous cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2017

Same author

Xenotransplantation of human intestine into mouse abdomen or subcutaneous tissue: Novel platforms for the study of the human enteric nervous system.

Neurogastroenterology and motility·2017

Using relatives of cases as controls for complex genetic diseases may not introduce bias. Our model suggests that even with correlated exposure status among relatives, this control selection method is valid for estimating effects.

Area of Science:

Epidemiology
Genetic Epidemiology
Biostatistics

Background:

Complex diseases with genetic components often utilize relatives of cases as controls.
Concerns exist regarding potential bias introduced by this control selection strategy.

Purpose of the Study:

To develop and apply a model for assessing bias in selecting relatives of cases as controls.
To evaluate the validity of using family members as controls in genetic disease studies.

Main Methods:

Developed a mathematical model to simulate bias.
Assumed constant exposure-specific disease risks over time.
Analyzed the impact of correlated exposure status among relatives.

Main Results:

Related Experiment Videos

The study's model indicates that selecting controls from relatives of cases does not inherently introduce bias.

This holds true even when there is a correlation in exposure status within families.

Bias is not an inevitable consequence of using relatives as controls.

Conclusions:

The selection of controls from relatives of cases is a potentially valid method for studying complex diseases.
This approach can be used without introducing bias in effect estimation, given certain assumptions.
Further research can confidently explore this control selection strategy in genetic epidemiology.