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Dramatic decrease of Streptococcus pneumoniae infections in Marseille, 2003-2014.

C Abat1, D Raoult1, J-M Rolain2

  • 1URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France.

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Summary
This summary is machine-generated.

National immunization programs significantly reduced pneumococcal infections in Marseille university hospitals between 2003 and 2014. This decrease was observed across all age groups, highlighting vaccination

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Pneumococcal infections, caused by Streptococcus pneumoniae, represent a significant global health burden.
  • Understanding the trends in pneumococcal infection prevalence is crucial for evaluating public health interventions.

Purpose of the Study:

  • To analyze the temporal evolution of pneumococcal infection prevalence in university hospitals in Marseille, France.
  • To compare regional trends with international data and assess the impact of national immunization programs.

Main Methods:

  • Retrospective analysis of hospitalized patients with Streptococcus pneumoniae infections from January 2003 to December 2014.
  • Calculation of annual infection percentages based on positive pneumococcal strains relative to total bacterial infections.
  • Statistical analysis to determine trends and correlations between age groups.

Main Results:

  • A significant decrease in the annual percentage of pneumococcal infections was observed, from 1.99% in 2003 to 0.77% in 2014 (p < 10^-4).
  • A strong positive correlation (r = 0.93, p < 10^-5) was found between the infection trends in patients under 21 and over 21 years old.
  • Overall, 2442 non-redundant patients were infected during the study period.

Conclusions:

  • National immunization programs have a demonstrable and effective impact on reducing pneumococcal infection prevalence.
  • The positive impact of vaccination is evident even on a regional scale and across different age demographics.
  • Continued surveillance is essential to monitor pneumococcal infection trends and the long-term effectiveness of vaccination strategies.