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Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and
1Pharmaceutical Research and Development Division, Bristol-Myers Company, Wallingford, Connecticut 06492.
The Journal of Antibiotics
|December 1, 1989
Abstract:
A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388 in mice.