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Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

Ashley M Laughney1, Sergi Elizalde2, Giulio Genovese3

  • 1Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell Reports
|July 28, 2015
PubMed
Summary

Cancer cells maintain a specific chromosome missegregation rate for optimal survival and diversity. This chromosomal instability drives tumor evolution by selecting for advantageous genetic changes.

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