Related Experiment Video
Updated: Apr 6, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.4K
Multidimensional Model of Disability and Role Functioning in Rheumatoid Arthritis
Sarah R Ormseth1, Taylor L Draper2, Michael R Irwin1
1Cousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California, Los Angeles.
Arthritis Care & Research
|July 28, 2015
Summary
Rheumatoid arthritis disease burden impacts role functioning primarily through mood disturbances and disability. Addressing these factors is key to improving daily life for RA patients.
Area of Science:
- Rheumatology
- Psychosomatic Medicine
- Rehabilitation Medicine
Background:
- Rheumatoid arthritis (RA) significantly impacts patients' quality of life.
- Understanding the mediators between disease burden and functional impairments is crucial for effective management.
Purpose of the Study:
- To investigate the mediating roles of mood disturbance and disability in the relationship between RA disease burden and impaired role functioning.
- To analyze the direct and indirect pathways linking RA disease burden to role functioning.
Main Methods:
- Cross-sectional study of 103 RA patients.
- Utilized validated assessments for disease burden, mood disturbance, disability, and role functioning.
- Employed structural equation modeling (SEM) to analyze mediational pathways.
Main Results:
- The proposed model demonstrated excellent fit, indicating robust relationships.
- RA disease burden was significantly associated with impaired role functioning.
- Mood disturbance and disability jointly mediated the effect of disease burden on role functioning, with disease burden losing significance when these factors were accounted for.
Conclusions:
- Mood disturbance and disability are critical mediators in how RA disease burden affects role functioning.
- Interventions targeting mood and disability may improve role functioning in RA patients.
- Further longitudinal research is recommended to confirm these mediational mechanisms.
Related Concept Videos
01:26Modeling in Therapy
724
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
724
01:23Rheumatic Heart Disease I: Introduction
892
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
892
01:24T Cell Types and Functions
3.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.3K
01:20Rheumatic Heart Disease IV: Nursing Management
455
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
455
01:21Dimensions of Health and Illness
12.0K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
12.0K
01:11Genome-wide Association Studies-GWAS
16.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.7K