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Updated: Apr 6, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Treatment withdrawal in relapsing-remitting multiple sclerosis: a retrospective cohort study
G Lus1, E Signoriello1, G T Maniscalco2
1Multiple Sclerosis Center, II Division of Neurology, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.
Background:
To investigate the effect of drug withdrawal on the course of relapsing-remitting multiple sclerosis (RR-MS).
Methods:
An observational cohort retrospective study was performed to compare the time to relapse of patients who discontinued disease-modifying therapy (1a or 1b beta-interferons or glatiramer acetate) with the patients who did not. One hundred and twenty-eight RR-MS patients were investigated using a time-dependent approach.
Results:
Over a median follow-up of 108 months, 60 patients discontinued treatment and 89 relapses were observed. The time to relapse was shorter in patients who discontinued treatment compared with those who did not (P < 0.001), median times being 31.1 months (95% confidence interval 10.4-50.8) and 85.8 months (95% confidence interval 58.6-106.3), respectively, whilst the baseline covariates (gender, Expanded Disability Status Scale at diagnosis) did not significantly affect the prognosis.
Conclusions:
It was found that stopping treatment strongly reduces the time to relapse and this information may be useful in patient management.
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