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Related Experiment Video

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Neurodevelopmental outcome after neonatal perforator stroke.

Ginette M Ecury-Goossen1, Marit van der Haer1, Liesbeth S Smit1,2

  • 1Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Developmental Medicine and Child Neurology
|July 28, 2015
PubMed
Summary

Neonatal perforator stroke outcomes were assessed in 37 children. Isolated strokes generally had favorable motor outcomes, but involvement of the internal capsule

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Area of Science:

  • Neurology
  • Pediatric Neurology
  • Neuroimaging

Background:

  • Neonatal stroke is a significant cause of long-term neurological deficits.
  • Perforator strokes, a specific type of neonatal stroke, require further investigation regarding their long-term sequelae.
  • Understanding outcome predictors is crucial for patient management and counseling.

Purpose of the Study:

  • To evaluate the long-term outcomes in a large cohort of children following neonatal perforator stroke.
  • To identify factors influencing recovery and the presence of neurological impairments such as cerebral palsy (CP).

Main Methods:

  • A cohort of 37 children diagnosed with neonatal perforator stroke via cranial ultrasound or MRI was studied.
  • Outcomes assessed included the Recovery and Recurrence Questionnaire score, cerebral palsy (CP), independent ambulation, regular education participation, and epilepsy.
  • Patients were categorized based on isolated perforator stroke(s) versus those with additional brain injury.

Main Results:

  • Four out of 18 children with isolated perforator stroke(s) developed CP, with three cases associated with posterior limb of the internal capsule involvement.
  • Among 19 children with additional brain injury, 11 had CP and three had difficulties walking independently.
  • Epilepsy was observed in three of nine children with concomitant cortical middle cerebral artery stroke.

Conclusions:

  • Perforator stroke patterns can aid in predicting long-term outcomes and guiding clinical management.
  • Motor outcomes are generally favorable in isolated perforator strokes, unless the posterior limb of the internal capsule is affected.