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Retrograde root filling using antibiotic-containing, radiopaque, bone cement.
Journal of Dentistry
|October 1, 1989
Summary
Gentamicin-containing bone cements show promise for retrograde root filling, offering better antibacterial properties and tissue compatibility than amalgam. While amalgam seals slightly better, these antibiotic cements present no apparent drawbacks in vitro.
Area of Science:
- Biomaterials Science
- Endodontics
- Infectious Diseases
Background:
- Retrograde root filling is crucial for endodontic treatment success.
- Amalgam has historically been used but possesses limitations.
- Gentamicin-containing bone cements offer potential antimicrobial benefits.
Purpose of the Study:
- To evaluate the in vitro performance of three gentamicin-containing radiopaque bone cements.
- To compare their properties against amalgam as retrograde root-filling materials.
Main Methods:
- Assessed bacteriocidal properties of cements.
- Evaluated tissue compatibility using cell culture.
- Determined sealing ability via dye diffusion tests.
- Compared results with amalgam.
Main Results:
- Gentamicin cements exhibited effective bacteriocidal properties.
- Cements demonstrated good tissue compatibility in cell culture.
- Amalgam showed superior apical sealing but poor antibacterial and tissue compatibility.
- No significant drawbacks were identified for the gentamicin cements.
Conclusions:
- Gentamicin-containing bone cements are promising retrograde root-filling materials.
- They offer distinct in vitro advantages over amalgam, particularly in antimicrobial activity and biocompatibility.
- Further in vivo studies are warranted to confirm these findings.