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Hepatitis associated with Mycoplasma pneumoniae infection in Korean children: a prospective study

Kyu Won Kim1, Jae Jin Sung1, Hann Tchah1

  • 1Department of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.

Korean Journal of Pediatrics
|July 28, 2015
PubMed
Abstract

Insights

Mycoplasma pneumoniae (MP) infection can cause hepatitis in children, affecting 7.7% of cases. This MP-associated hepatitis typically resolves within 7.5 days with a good prognosis, warranting clinical awareness but avoiding excessive evaluation.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Mycoplasma pneumoniae (MP) is a common cause of respiratory illness in children.
  • Extrapulmonary manifestations of MP are known, but hepatitis is rarely reported.
  • Understanding MP-associated hepatitis is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To investigate the clinical characteristics of hepatitis associated with Mycoplasma pneumoniae infection in pediatric patients.
  • To determine the incidence and clinical presentation of MP-associated hepatitis.
  • To assess the prognosis and outcomes of MP-associated hepatitis.

Main Methods:

  • A prospective study of 1,044 pediatric patients with MP infection was conducted.
  • Eighty patients with elevated AST/ALT levels (hepatitis) were compared to 964 without liver involvement.
  • Diagnosis was confirmed serologically for MP IgM.

Main Results:

  • Hepatitis was diagnosed in 7.7% of pediatric MP infections, predominantly in fall/winter.
  • Common symptoms included cough, fever, anorexia, and elevated AST/ALT levels.
  • Liver enzyme levels normalized within 7.5 days, with a longer hospitalization for hepatitis cases.

Conclusions:

  • MP-associated hepatitis is a recognized, albeit uncommon, complication of MP infection in children.
  • The condition generally has a favorable prognosis with prompt resolution.
  • Clinicians should consider MP hepatitis in pediatric patients but avoid unnecessary investigations.
Keywords:
HepatitisMacrolidesMycoplasma pneumoniae

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