Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

341
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
341
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

762
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
762
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

378
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
378
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

484
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
484
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

8.9K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.9K
Pedigree Analysis01:35

Pedigree Analysis

91.1K
Overview
91.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Embryonic stem cell biology.

Advances in pediatrics·2008
Same author

Fraser syndrome: affected siblings born to nonconsanguineous parents and diagnosed at autopsy.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2007
Same author

The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation.

The Journal of biological chemistry·2007
Same author

Reference values for valve circumferences and ventricular wall thicknesses of fetal and neonatal hearts.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2004
Same author

Reference values for second trimester fetal and neonatal organ weights and measurements.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2003
Same author

Utility of HPV DNA detection in thin-layer, liquid-based tests with atypical squamous metaplasia.

Acta cytologica·2002

Related Experiment Video

Updated: Apr 6, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K

Pediatric Pathology In The Year 2050.

Don B Singer1

  • 1Department of Pathology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Street, Madison, WI 53705, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|July 28, 2015
PubMed
Summary

Pediatric pathology is evolving with nanotechnology, enabling earlier disease detection and personalized treatments. Future advancements promise faster diagnostics and improved patient outcomes through integrated data and automated laboratory processes.

Keywords:
crowdsourcenanotechnologyomniscoperobotssmartphone

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.7K
Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 6, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.7K
Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

1.4K

Area of Science:

  • Pediatric Pathology
  • Nanotechnology in Medicine
  • Medical Diagnostics

Background:

  • The field of pediatric pathology originated in the mid-19th century.
  • Current pediatric pathology practices are evolving with technological integration.
  • Medical practitioners are beginning to explore nanotechnology's potential.

Observation:

  • Nanotechnology involves the study of structures and activities at the atomic and molecular level.
  • By 2050, nanotechnology is expected to drive the discovery of new and altered diseases.
  • Crowd-sourced medical data will be interconnected with scientific findings via computers.

Findings:

  • Pediatric pathologists will utilize advanced laboratory instruments like Omniscopes.
  • Robotic automation will be employed for autopsies and surgical specimen processing.
  • Next-generation analyzers will provide rapid results in chemistry, microbiology, hematology, and genetics.

Implications:

  • Technological integration in pathology will enhance diagnostic accuracy and speed.
  • Future advancements are poised to revolutionize pediatric healthcare and patient outcomes.
  • Personalized medicine and targeted therapies will become more prevalent.