Related Experiment Video
Updated: Apr 6, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
Sodium-activated macrophages: the salt mine expands
Liliana E Lucca1, David A Hafler1
1Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
Abstract:
High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature, paving the path to assess the role of salt-activated macrophages in human disease.
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