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Related Experiment Video

Updated: Apr 6, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
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Glucocorticoids and Skeletal Muscle.

Sue C Bodine1, J David Furlow

  • 1Department of Neurobiology, Physiology and Behavior, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA, scbodine@ucdavis.edu.

Advances in Experimental Medicine and Biology
|July 29, 2015
PubMed
Summary

Glucocorticoids cause muscle atrophy by disrupting protein metabolism. This effect is significant in diseases and from medical treatments, leading to muscle loss and weakness.

Area of Science:

  • Biochemistry
  • Physiology
  • Endocrinology

Background:

  • Glucocorticoids regulate protein metabolism, opposing insulin's anabolic effects.
  • Elevated endogenous glucocorticoids in catabolic diseases (sepsis, starvation, cancer cachexia) contribute to muscle wasting.
  • Exogenous glucocorticoids, used for inflammatory conditions, can cause muscle atrophy with acute or chronic use.

Purpose of the Study:

  • To detail the nature of glucocorticoid-induced muscle atrophy.
  • To discuss the proposed mechanisms behind glucocorticoid catabolism in muscle.

Main Methods:

  • Review of existing literature on glucocorticoid effects on skeletal muscle protein metabolism.
  • Analysis of mechanisms contributing to muscle atrophy induced by glucocorticoids.

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Main Results:

  • Glucocorticoids exert a catabolic effect on skeletal muscle protein.
  • Both endogenous and exogenous glucocorticoid excess contribute to muscle mass and function loss.
  • Specific mechanisms underlying glucocorticoid-induced muscle atrophy are identified.

Conclusions:

  • Glucocorticoid action is a key factor in muscle wasting associated with various diseases and treatments.
  • Understanding these mechanisms is crucial for managing muscle atrophy in clinical settings.