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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
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Mesenchymal Stem Cells: Key Actors in Tumor Niche
Sanaa El Marsafy1, Jérôme Larghero
1Assistance Publique-Hopitaux de Paris. Hopital Paul Brousse. Laboratoire d'Hematologie Biologique. Villejuif, France. elmarsafy.sanaa7@yahoo.fr.
Current Stem Cell Research & Therapy
|July 29, 2015
Summary
Tumors thrive in a cancer niche, interacting with mesenchymal stem cells (MSC) and other components. Understanding this crosstalk is key to developing new anti-tumor therapies.
Area of Science:
- Oncology
- Cancer Biology
- Stem Cell Research
Background:
- Tumors develop within a specialized microenvironment known as the cancer niche.
- The cancer niche comprises cancer cells, mesenchymal stem cells (MSC), fibroblasts, vasculature, immune cells, extracellular matrix (ECM), cytokines, chemokines, and growth factors.
Purpose of the Study:
- To investigate the bidirectional relationship between MSC and cancer cells.
- To understand the impact of this interaction on tumor progression.
Main Methods:
- Focus on the crosstalk between cancer cells and MSC within the tumor niche.
- Review of existing literature on MSC-cancer cell interactions and tumor progression.
Main Results:
- Bidirectional communication between MSC and cancer cells significantly influences tumor growth and metastasis.
- MSC contribute to creating a supportive microenvironment for tumor progression.
Conclusions:
- Understanding the intricate crosstalk within the tumor niche, particularly between MSC and cancer cells, is crucial.
- This knowledge can guide the development of novel and effective anti-tumor therapeutic strategies.
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