Retracted: Expression and Function of PPARs in Cancer Stem Cells

Area of Science:

• Oncology
• Molecular Biology
• Cell Biology

Background:

• Cancer stem cells (CSCs) possess stem cell-like properties, driving tumor initiation, metastasis, and recurrence.
• Peroxisome-proliferator-activated receptors (PPARs) are transcription factors implicated in cancer development and tumorigenesis.
• PPARs are known to influence the epithelial-mesenchymal transition (EMT) process crucial for CSC initiation and function, though mechanisms are unclear.

Purpose of the Study:

• To review current evidence on the regulatory roles and mechanisms of PPARs in CSC formation and function.
• To evaluate the potential of PPARs as therapeutic targets for anti-cancer strategies.

Main Methods:

• Literature review of recent studies on PPARs and CSCs.
• Analysis of molecular mechanisms linking PPARs to CSC regulation.
• Evaluation of preclinical and clinical data regarding PPAR-targeted cancer therapies.

Main Results:

• PPARs modulate key CSC characteristics, including self-renewal and differentiation.
• PPARs influence EMT, a critical process in CSC initiation and metastatic potential.
• Evidence suggests PPARs can impact CSC resistance to conventional therapies.

Conclusions:

• PPARs play a significant role in regulating CSCs, impacting tumor initiation, metastasis, and therapeutic resistance.
• Targeting PPARs presents a promising strategy for novel anti-cancer treatments aimed at eliminating CSCs.