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MEG-measured auditory steady-state oscillations show high test-retest reliability: A sensor and source-space analysis
H-R M Tan1, J Gross1, P J Uhlhaas1
1Centre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology (INP), College of Medical, Veterinary and Life Sciences & College of Science and Engineering, University of Glasgow, 58 Hillhead Street, Glasgow G12 8QB, Scotland, United Kingdom.
Neuroimage
|July 29, 2015
Summary
Magnetoencephalography (MEG) reliably measures auditory steady-state responses (ASSRs). This study confirms the reproducibility of spectral power and inter-trial phase coherence (ITPC) for ASSRs in MEG data.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Biomedical Engineering
Background:
- Assessing the stability of oscillatory signatures in magnetoencephalography (MEG) is crucial for reliable basic and clinical research.
- Previous studies have not sufficiently addressed the test-retest reliability of specific neural responses like auditory steady-state responses (ASSRs).
Purpose of the Study:
- To evaluate the test-retest reliability of auditory steady-state responses (ASSRs) using magnetoencephalography (MEG).
- To compare the reliability of spectral power changes versus inter-trial phase coherence (ITPC) for ASSRs.
Main Methods:
- Thirteen participants underwent two MEG sessions, performing a tone detection task with 5 Hz or 40 Hz amplitude-modulated (AM) tones.
- Intraclass correlations (ICCs) were calculated to assess the stability of spectral power and ITPC of ASSRs.
- Source activity was localized using eLORETA beamforming in the auditory cortex.
Main Results:
- Auditory steady-state responses (ASSRs) to 40 Hz AM stimuli showed stronger power modulation and phase-locking than 5 Hz stimuli.
- Both spectral power and ITPC demonstrated robust test-retest reliability (high ICC values) at sensor and source levels.
- Inter-trial phase coherence (ITPC) measures exhibited higher reliability (ICCs ~0.86-0.96) compared to spectral power changes (ICCs ~0.61-0.82).
Conclusions:
- Magnetoencephalography (MEG) measurements of spectral modulations and phase consistency in auditory steady-state responses (ASSRs) are highly reproducible.
- The findings support the use of MEG-measured oscillatory parameters, particularly ITPC, in both basic and clinical neuroscience research.
- This study establishes a foundation for utilizing ASSRs in MEG for longitudinal studies and clinical applications.
