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Updated: Apr 6, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Chemotherapy in Prostate Cancer.
1Yale Comprehensive Cancer Center, 333 Cedar Street, New Haven, CT, 06520, USA, michael.hurwitz@yale.edu.
Current Oncology Reports
|July 29, 2015
Summary
Chemotherapy prolongs life for metastatic castration-resistant prostate cancer (mCRPC). Recent advances include adding chemotherapy to hormonal therapy for castration-sensitive disease, with ongoing research into new treatments and resistance mechanisms.
Area of Science:
- Oncology
- Urology
- Pharmacology
Background:
- Chemotherapy has been a cornerstone in extending survival for metastatic castration-resistant prostate cancer (mCRPC) for about ten years.
- Limited life-prolonging agents (docetaxel, cabazitaxel) have been approved for mCRPC.
- Recent guidelines now recommend chemotherapy combined with primary hormonal therapy for high-volume castration-sensitive metastatic prostate cancer.
Purpose of the Study:
- To review current chemotherapy options for prostate cancer.
- To discuss established and emerging mechanisms of chemotherapy resistance.
- To highlight ongoing clinical trials investigating novel chemotherapeutics and combination strategies.
Main Methods:
- Literature review of current prostate cancer chemotherapies.
- Analysis of mechanisms of resistance to chemotherapy.
- Overview of ongoing clinical studies and novel agents.
Main Results:
- Docetaxel and cabazitaxel remain key agents in mCRPC treatment.
- Combination chemotherapy with hormonal therapy is now standard for high-volume castration-sensitive disease.
- Research is actively exploring new chemotherapeutic agents and strategies to overcome resistance.
Conclusions:
- Chemotherapy plays a vital role in managing advanced prostate cancer.
- Understanding and overcoming resistance mechanisms is crucial for improving patient outcomes.
- Ongoing research promises to expand the therapeutic armamentarium for prostate cancer patients.
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