Related Experiment Video

Updated: Apr 6, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.4K

[MicroRNAs in kidney fibrosis]

Cynthia Van der Hauwaert1, Grégoire Savary1, Marie-Flore Hennino1

  • 1EA4483, pôle recherche, faculté de médecine de Lille, université de Lille, 1, place de Verdun, 59045 Lille cedex, France.

Nephrologie & Therapeutique
|July 29, 2015
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in kidney fibrosis, a major cause of chronic kidney disease. Understanding their role offers new diagnostic and therapeutic strategies for kidney fibrogenesis.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Renal fibrosis is the final, irreversible stage of chronic kidney diseases.
  • It involves extracellular matrix accumulation, impairing kidney function.
  • The molecular mechanisms of renal fibrosis are complex and not fully understood.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in kidney fibrogenesis.
  • To discuss the potential of miRNAs as diagnostic and therapeutic targets.
  • To explore future research directions in miRNA-mediated kidney fibrosis.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of studies investigating miRNA involvement in kidney fibrosis.
  • Synthesis of information on miRNA regulatory functions.

Main Results:

  • MicroRNAs (miRNAs) play a significant profibrotic role in kidney fibrosis.
  • miRNAs regulate gene expression post-transcriptionally.
  • Emerging evidence highlights miRNAs as potential biomarkers and therapeutic targets.

Conclusions:

  • MicroRNAs are crucial in kidney fibrogenesis.
  • Targeting miRNAs may offer novel therapeutic strategies for chronic kidney diseases.
  • Further research is needed to fully elucidate miRNA functions and clinical applications.
Keywords:
BiomarkersBiomarqueurFibrose rénaleMicroARNMicroRNARenal fibrosis

More Related Videos

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.9K
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.2K

Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.2K
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.2K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1000
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
504
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.9K