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Related Experiment Video

Updated: Apr 6, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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A long-term patient perspective after hemispherotomy--a population based study.

Cecilia Verdinelli1, Ingrid Olsson1, Anna Edelvik2

  • 1Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Seizure
|July 29, 2015
PubMed
Summary

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Hemispherotomy surgery in Sweden showed long-term seizure recurrence in 65% of patients. However, most patients reported good quality of life and satisfaction with the epilepsy surgery, even if seizures persisted.

Area of Science:

  • Neurosurgery
  • Epileptology
  • Quality of Life Research

Background:

  • Hemispherotomy is a surgical option for intractable epilepsy.
  • Long-term outcomes beyond seizure control are crucial for patient well-being.

Purpose of the Study:

  • To evaluate the long-term life situation of Swedish hemispherotomy patients.
  • Assess seizure outcomes, functional status, quality of life (QoL), and surgical satisfaction.

Main Methods:

  • Population-based study using the Swedish National Epilepsy Surgery Register.
  • Prospective data collection with long-term follow-up (5-10 years).
  • Independent interviews using patient-oriented questionnaires.

Main Results:

Keywords:
HemispherotomyLong-termOutcomePatient perspectiveQuality of life

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  • 29 patients underwent hemispherotomy; 38% were seizure-free at long-term follow-up (median 13.5 years).
  • Among non-seizure-free patients, seizures were mild/moderate; 23% discontinued antiepileptic medication.
  • Most patients reported good QoL and general health; 73% were satisfied with the hemispherotomy.

    • Conclusions:

    • Higher long-term seizure recurrence observed compared to previous reports, potentially due to cohort characteristics.
    • Despite persistent impairments, most hemispherotomy patients experience good long-term QoL and view the surgery as worthwhile.
    • Reduction in seizure frequency/severity may be a significant benefit, even if complete seizure freedom is not achieved.