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Updated: Apr 6, 2026

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

Published on: September 21, 2014

Data for mitochondrial proteomic alterations in the developing rat brain.

Lance M Villeneuve¹, Kelly L Stauch¹, Howard S Fox¹

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.

|July 29, 2015

Summary

This summary is machine-generated.

This study examined mitochondrial protein changes during early brain development. Researchers found significant alterations in energy metabolism and mitochondrial maintenance pathways, offering insights into normal brain development.

Keywords:

Development Mitochondria Oxygen tension Proteomics

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Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

Area of Science:

Cell Biology
Neuroscience
Biochemistry

Background:

Mitochondria are vital for neuronal energy production.
Research often overlooks mitochondrial homeostatic responses to energy demands during development.
Neuronal cells heavily depend on mitochondrial function.

Purpose of the Study:

To investigate mitochondrial proteome alterations during embryonic to early postnatal brain development (E18-P7).
To identify homeostatic responses of mitochondria to changing energy demands.
To understand developmental changes in mitochondrial protein interactions.

Main Methods:

Quantitative proteomic analysis of mitochondrial and associated proteins.
Focus on the E18 to P7 developmental window in rat brains.
Analysis of protein alterations in key cellular pathways.

Main Results:

Identified significant changes in proteins involved in glycolysis and energy production.
Observed alterations in mitochondrial trafficking and mitophagy pathways.
Detected modifications in the unfolded protein response related to mitochondrial function.

Conclusions:

Mitochondria exhibit homeostatic adaptations during critical brain development phases.
These findings provide a baseline for identifying aberrant mitochondrial proteomes.
Understanding these developmental changes is crucial for brain health research.