Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells

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Updated: Apr 6, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K

Orit Uziel1, Meir Lahav1

  • 1The Felsenstein Medical Research Center, Rabin Medical Center and Sackler School of Medicine, Tel Aviv University, Israel.

Data in Brief
|July 29, 2015
PubMed

Insights

Shortening cancer cell telomeres enhances cisplatinum sensitivity and impairs DNA repair. Network modeling identified key proteins mediating these effects, aiding new therapeutic development.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genomics

Background:

  • Previous studies demonstrated telomere shortening sensitizes cancer cells to cisplatinum, reduces migration, and impairs DNA repair.
  • Understanding the molecular mechanisms behind these telomere-shortening effects is crucial for developing novel cancer therapeutics.

Purpose of the Study:

  • To decipher the molecular mechanisms underlying the phenotypic effects of shortened telomeres in cancer cells.
  • To construct a network model integrating microRNA and proteomic data to identify key mediators.
  • To provide full proteomic and microarray data for cells with shortened versus intact telomeres.

Main Methods:

  • Network modeling integrating microRNA and proteomic profiling.
  • Experimental validation of identified protein expression candidates.
  • Microarray analysis of cells with shortened telomeres compared to parental cells.

Main Results:

  • A network model identified several nodal candidates potentially mediating shortened-telomere dependent phenotypes.
  • Experimental validation supported the central role of these identified protein expressions.
  • Full proteomic and microarray data are provided for comparative analysis.

Conclusions:

  • Clarifying the mechanism of telomere shortening can facilitate novel therapeutics development.
  • This research provides valuable data for understanding telomere biology in cancer.
  • Identifying key molecular mediators may offer alternative strategies to telomere shortening via telomerase inhibition.

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