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Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Related Experiment Video

Updated: Apr 6, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Data for mitochondrial proteomic alterations in the aging mouse brain.

Kelly L Stauch¹, Phillip R Purnell¹, Lance M Villeneuve¹

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.

|July 29, 2015

Summary

This summary is machine-generated.

Mitochondrial dysfunction impacts brain energy metabolism during aging. This study reveals age-associated proteomic changes in brain mitochondria, suggesting altered catabolic pathways in aging brains.

Keywords:

Aging Mitochondria Proteomics

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Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Mitochondria are vital organelles for cellular energy production.
Mitochondrial dysfunction is implicated in age-related changes in brain glucose metabolism.
Limited quantitative proteomic data exists on mitochondrial changes during brain aging.

Purpose of the Study:

To comprehensively characterize age-associated proteomic alterations in brain mitochondria.
To investigate the role of mitochondrial changes in brain aging and metabolism.

Main Methods:

Quantitative mass spectrometry was used to analyze brain mitochondria from mice of different ages (5, 12, and 24 months).
Proteomic profiling identified changes in protein expression levels.

Main Results:

Significant age-associated changes in mitochondrial protein expression were identified.
Alterations were observed in proteins involved in the generation of precursor metabolites and energy.
Results suggest modified mitochondrial catabolic reactions during brain aging.

Conclusions:

Brain mitochondria undergo significant proteomic changes with age.
These changes indicate altered energy metabolism pathways in the aging brain.
The findings provide insights into the molecular mechanisms of brain aging.