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Updated: Apr 6, 2026

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Published on: January 20, 2022
Sensitivity and robustness enhancements by using a V-shape ion funnel in FTICR-MS
Liulin Deng1,2, Xiangfeng Chen1,3, Wan Li1
1†Department of Chemistry, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China.
Abstract:
In this paper, a new configuration of the ion funnel interface (i.e., V-shape ion funnel (V-IF)) for high ion transmission efficiency and robustness enhancement was developed and implemented on FTICR-MS. The performance of the V-IF was compared with that of a home-built orthogonal ion funnel. An order of magnitude of improvement in sensitivity was achieved for various peptides and proteins. The performance of the instrument was maintained for a long period by neutral molecule removal. Other ion transmission patterns, such as gentle ion transmission, adduct ion removal, and radio frequency (RF)-driven collision induced dissociation (CID), was also realized in V-IF by varying the RF potentials. V-IF is believed to be a novel ion guide that has promising applications in mass spectrometry.
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