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Updated: Apr 6, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
16.8K
[Malignant head and neck melanoma: Part 2: Therapy]
C Pföhler1, T Vogt, C S L Müller
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, Kirrbergerstrasse, 66421, Homburg/Saar, Deutschland, claudia.pfoehler@uks.eu.
HNO
|July 30, 2015
Summary
Treatment for head and neck melanomas involves adapting surgical margins and considering adjuvant therapies like interferon-α or radiotherapy. Systemic treatments, including chemotherapy and targeted therapies, are options for advanced or metastatic disease.
Area of Science:
- Oncology
- Dermatology
- Surgical Oncology
Context:
- Head and neck melanomas present unique surgical challenges due to anatomical constraints.
- Adjuvant and systemic therapies are crucial for managing advanced or metastatic disease.
Purpose:
- To outline the multimodal treatment strategies for head and neck melanomas.
- To discuss the role of surgery, adjuvant therapies, and systemic treatments.
Summary:
- Surgical resection margins for head and neck melanomas require adaptation based on anatomy.
- Adjuvant interferon-α or radiotherapy may be used for thicker tumors or after lymph node metastasis resection.
- Systemic treatments, including chemotherapy and targeted therapies (BRAF, MEK, kinase inhibitors), are vital for inoperable metastases.
Impact:
- Provides a concise overview of treatment options for head and neck melanoma.
- Highlights the importance of tailored surgical approaches and modern systemic therapies.
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