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The somatotropic axis and longevity in mice.

H M Brown-Borg1

  • 1Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota holly.brown.borg@med.und.edu.

American Journal of Physiology. Endocrinology and Metabolism
|July 30, 2015
PubMed
Summary

The somatotropic signaling pathway influences aging and lifespan in mice. Growth hormone and insulin-like growth factor I play key roles in aging processes and longevity.

Keywords:
aginggrowth hormoneinsulin-like growth factorlifespan regulation

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Area of Science:

  • Aging research
  • Endocrinology
  • Genetics

Background:

  • The somatotropic signaling pathway, involving growth hormone and insulin-like growth factor I, is crucial in aging and longevity studies.
  • Mutant mice models have significantly advanced the understanding of how this pathway affects aging-related processes and lifespan.
  • Longer-living mice often display altered growth factor levels, though phenotypic complexity can influence lifespan.

Purpose of the Study:

  • To explore the role of the somatotropic signaling pathway in aging and longevity.
  • To understand the impact of growth hormone and insulin-like growth factor I on aging processes.
  • To investigate the relationship between somatotropic axis variations and lifespan in mice.

Main Methods:

  • Analysis of physiological and lifespan data from various spontaneous and genetically engineered mutant mice.
  • Comparison of growth factor levels in long-lived mice versus wild-type controls.
  • Examination of how the somatotropic axis influences key metabolic and stress resistance pathways.

Main Results:

  • The somatotropic pathway is strongly implicated in regulating aging and lifespan across species.
  • Mutant mice with altered somatotropic signaling exhibit diverse physiological changes impacting longevity.
  • Differences in growth factor levels are observed in longer-living mouse models, alongside complex phenotypic variations.

Conclusions:

  • The somatotropic axis is a key regulator of aging and lifespan, influencing critical pathways like insulin sensitivity, nutrient sensing, mitochondrial function, and stress resistance.
  • Understanding the somatotropic pathway's role in mice provides insights into conserved mechanisms of aging and longevity.
  • Further research into the complex interplay of genetics, physiology, and the somatotropic axis is essential for aging and longevity studies.