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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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Interaction preferences between nucleobase mimetics and amino acids in aqueous solutions

Matea Hajnic1, Juan I Osorio, Bojan Zagrovic

  • 1Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, Vienna 1030, Austria. bojan.zagrovic@univie.ac.at.

Physical Chemistry Chemical Physics : PCCP
|July 30, 2015
PubMed
Summary

Protein-nucleic acid interactions are crucial but poorly understood. Our study reveals hydrophobic effects drive amino acid interactions with nucleobase mimetics, with specificity likely arising from ring substituents, not the core rings themselves.

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