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Sustained Arc expression in adult-generated granule cells.

Alicia Meconi1, Erika Lui1, Diano F Marrone2

  • 1Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

Neuroscience Letters
|July 30, 2015
PubMed
Summary

Newly generated neurons in the dentate gyrus (DG) exhibit sustained Arc gene transcription after experiencing new environments. This finding reveals how young neurons contribute to memory plasticity and distinct event representations.

Keywords:
Arg3.1Dentate gyrusNeurogenesis

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Memory Research

Background:

  • The dentate gyrus (DG) is crucial for memory formation and exhibits unique properties, including adult neurogenesis.
  • The immediate-early gene Arc shows sustained transcription in response to sensory input in the DG.
  • It is unknown if adult-generated neurons in the DG display sustained Arc transcription like mature neurons.

Purpose of the Study:

  • To investigate whether newly generated neurons in the adult dentate gyrus exhibit sustained Arc gene transcription following behavioral experience.
  • To determine the temporal dynamics of Arc expression in adult-generated neurons after environmental exploration.

Main Methods:

  • Adult F344 rats were administered BrdU to label dividing cells.
  • Four weeks post-BrdU injection, rats explored a novel environment.
  • Arc expression was quantified in BrdU-labeled (newly generated) and unlabeled (mature) neurons at various time points (0.5h to 24h) after exploration.

Main Results:

  • Recently-generated granule cells in the DG demonstrated robust, sustained Arc expression following the novel environment experience.
  • This sustained Arc expression was observed in both adult-generated and developmentally-generated neurons.

Conclusions:

  • Adult-generated neurons are capable of sustained Arc transcription in response to behavioral activity, similar to mature neurons.
  • This sustained transcription in new neurons may contribute to the formation of distinct and uncorrelated memory representations.
  • This provides insight into a potential mechanism for sculpting memory representations of temporally close events.