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Mechanically switchable solid inhomogeneous phantom for performance tests in diffuse imaging and spectroscopy.

Antonio Pifferi¹, Alessandro Torricelli¹, Rinaldo Cubeddu²

¹Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano 20133, Italy.

Journal of Biomedical Optics

|July 30, 2015

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This summary is machine-generated.

A novel solid phantom with adjustable absorption was created for optical imaging. This tool aids in the quality control of functional near-infrared spectroscopy (fNIRS) instruments.

Area of Science:

Biomedical Optics
Optical Phantoms
Diffuse Optics

Background:

Accurate characterization of optical instruments is crucial for reliable biomedical measurements.
Developing phantoms that mimic biological tissue properties is essential for instrument calibration and validation.
Functional near-infrared spectroscopy (fNIRS) requires robust phantoms for performance assessment.

Purpose of the Study:

To develop and characterize a mechanically switchable solid inhomogeneous phantom.
To simulate localized absorption changes for testing optical instruments.
To provide a tool for the quality control of clinical instruments and industrial standards.

Main Methods:

Fabrication of a homogeneous epoxy resin phantom with absorbing (black toner) and scattering (titanium dioxide) components.

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Inclusion of a movable polyvinyl chloride cylinder within the phantom to create adjustable absorption perturbations.

Characterization using time-domain diffuse optics instruments, measuring absorption/scattering spectra, transmittance images, and reflectance contrast.

Testing the phantom's performance for fNIRS by measuring reflectance contrast with varying inclusion volumes and positions.

Main Results:

The phantom successfully simulates localized absorption changes through mechanical manipulation of an embedded inclusion.
Characterization confirmed the phantom's ability to generate a wide range of absorption perturbation magnitudes.
Reflectance contrast measurements demonstrated the phantom's utility for fNIRS performance evaluation across different inclusion sizes and positions.

Conclusions:

A versatile, mechanically switchable solid phantom for simulating absorption changes in diffuse optics has been developed.
This phantom serves as a valuable tool for routine quality checks and the implementation of industrial standards for optical instruments.
Further experimental characterization is recommended for its widespread adoption in clinical and industrial settings.