Dixon-based fat-free MR-angiography compared to first pass and steady-state high-resolution MR-angiography using a...

Compared to standard arterial-only first-pass MR-angiography (FPMRA), imaging during the equilibrium phase of a blood pool contrast agent (steady state) has been shown to provide higher image quality and better stenosis grading. Homogenous Dixon fat-suppression promises to increase contrast by suppression of fat adjacent to vessels. This study was performed to compare diagnostic image quality and vessel-to-background contrasts in equilibrium phase Dixon-based fat-free MRA (DFSMRA) of run-off vessels to FPMRA imaging and equilibrium phase T1-weighted non-fat-suppressed ultra-high resolution MRA (SSMRA).

In a prospective, intra-individual comparative study, 17 patients with known or suspected peripheral arterial occlusive disease (PAOD; 11 men, mean age 65.6±18.1 [23-89] years) received FPMRA, DFSMRA, and SSMRA at 1.5 Tesla using a clinical whole body MRI scanner. All sequences were performed within the same session applying a single dose of a blood pool contrast agent (gadofosveset trisodium) that was injected during acquisition of FPMRA. The diagnostic image quality of the run-off vessels was evaluated on a 3-point scale. Quantitative analysis consisted of contrast-ratio (CR) measurements of vascular lumen signals compared to signals of adjacent muscle and fat.

The average image quality of vessel visualization was rated highest in SSMRA (mean 1.34±0.41), followed by standard FPMRA (mean 1.15±0.33) and DFSMRA (mean 0.99±0.61). Image quality was rated similarly high in the thighs and pelvic region, whereas small vessels in the lower legs and in the feet were best visualized by SSMRA. CR of vascular lumen compared to adjacent fatty tissue was 2.7 times higher in DFSMRA compared to SSMRA, whereas CR of vascular lumen to muscle was 1.3 times higher in SSMRA.

Vessel to fat contrast is strongly increased in DFSMRA compared to T1-weighted ultra-high resolution non-fat suppressed SSMRA, whereas vessel to muscle contrast is decreased in DFSMRA. Given the current technical limitations of DFSMRA, possible benefits are outweighed by advantages of first-pass imaging regarding arterial selectivity as well as advantages of SSMRA with respect to spatial resolution.