Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.9K

Posterior reversible leukoencephalopathy syndrome with spinal cord involvement in a 9-year-old girl

Uluç Yiş1, Pakize Karaoğlu1, Semra Hız Kurul1

  • 1Dokuz Eylül University, School of Medicine, Department of Pediatrics, Division of Pediatric Neurology, İzmir, Turkey.

Brain & Development
|July 30, 2015
PubMed

Insights

This study details the youngest pediatric patient diagnosed with posterior reversible encephalopathy syndrome (PRES) affecting the brainstem and spinal cord. Severe hypertension, even with minimal symptoms, can cause spinal PRES, highlighting the need for clinical awareness.

Area of Science:

  • Neurology
  • Pediatrics
  • Nephrology

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is a neurological condition.
  • PRES typically affects the brain's white matter.
  • Spinal cord involvement in pediatric PRES is rare.

Observation:

  • A pediatric patient presented with bicytopenia, renal dysfunction, and visual disturbances.
  • Cerebrospinal fluid analysis revealed elevated protein, IgG index, and cell count.
  • Magnetic resonance imaging showed extensive lesions in the brainstem and spinal cord.

Findings:

  • The patient was diagnosed with severe hypertension secondary to reflux nephropathy.
  • This case represents the youngest pediatric diagnosis of PRES.
  • The lesions were confined to the brainstem and spinal cord, a rare presentation.

Implications:

  • Severe hypertension can precipitate spinal PRES by exceeding autoregulation in the spinal cord's anterior territory.
  • Clinicians must consider spinal PRES in pediatric cases with extensive brainstem and spinal cord lesions.
  • The phenomenon of "clinical radiologic dissociation" (minimal symptoms despite significant imaging findings) is crucial for diagnosis.

Keywords:
ChildMyelitisPosterior reversible leukoencephalopathy syndromeSpinal cord

More Related Videos

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus14:59

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Published on: October 14, 2022

11.7K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
30
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
115