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Autism Spectrum Disorders: Translating human deficits into mouse behavior.

E Pasciuto1, S C Borrie1, A K Kanellopoulos1

  • 1KU Leuven, Center for Human Genetics, Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB Center for the Biology of Disease, Leuven, Belgium.

Neurobiology of Learning and Memory
|July 30, 2015
PubMed
Summary
This summary is machine-generated.

This review explores how mouse models are used to study Autism Spectrum Disorders (ASDs), focusing on behavioral phenotypes and genetic models to understand causes and find therapeutic targets.

Keywords:
Autism Spectrum DisordersCognitive impairmentHuman behaviorHyperactivityMouse behaviorRepetitive behaviorsSocial interaction

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Autism Spectrum Disorders (ASDs) are complex neurodevelopmental conditions with increasing prevalence.
  • Current diagnostic criteria include social interaction/communication deficits and repetitive behaviors.
  • Limited effective therapeutic interventions necessitate research into underlying mechanisms.

Purpose of the Study:

  • To review the utility of mouse models in studying ASD behavioral phenotypes.
  • To discuss genetic mouse models that recapitulate core ASD symptoms.
  • To highlight potential signaling pathways and cellular targets for future drug development.

Main Methods:

  • Review of existing literature on ASD mouse models.
  • Analysis of behavioral assays used to assess ASD-like phenotypes in mice.
  • Examination of genetic modifications in mice linked to ASD.

Main Results:

  • Mice are a common and valuable model for investigating ASDs.
  • Specific genetic mouse models exhibit behavioral features mirroring human ASD symptoms.
  • These models aid in understanding the neurobiological underpinnings of ASD.

Conclusions:

  • Mouse models are crucial for advancing ASD research.
  • Studying behavioral phenotypes in genetically modified mice offers insights into ASD pathogenesis.
  • This research can inform the development of novel therapeutic strategies for ASD.