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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Curcumin Resource Database.

Anil Kumar1, Hasnahana Chetia2, Swagata Sharma2

  • 1Bioengineering Research Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Assam 781039, India, Centre for Biological Sciences (Bioinformatics), Central University of South Bihar (CUSB), Patna 800014, India.

Database : the Journal of Biological Databases and Curation
|July 30, 2015
PubMed
Summary

A new Curcumin Resource Database (CRDB) centralizes data on curcumin and its analogs. This resource aids researchers in drug design and understanding curcuminoids from Curcuma longa.

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Bioinformatics

Background:

  • Curcumin, a diarylheptanoid from Curcuma longa, and its synthetic analogs (curcuminoids) show significant therapeutic and technological potential.
  • A critical gap exists in accessible, unified data for curcumin and curcuminoid research.
  • Existing data fragmentation hinders progress in structure-based and ligand-based molecular design.

Purpose of the Study:

  • To develop a comprehensive, centralized data repository for curcumin and its analogs.
  • To facilitate data accessibility and mining for researchers in the field.
  • To support the advancement of medicinal chemistry and drug discovery involving curcuminoids.

Main Methods:

  • Extensive data mining from diverse scientific and patent literature.
  • Careful curation of information on curcumin analogs, molecular targets, publications, patents, and Curcuma longa varieties.
  • Development of a user-friendly web interface with an integrated search engine.

Main Results:

  • The Curcumin Resource Database (CRDB) now contains 1186 curcumin analogs, 195 molecular targets, 9075 publications, 489 patents, and 176 Curcuma longa varieties.
  • Each entry is assigned a unique CRDB ID for precise identification.
  • The database provides cross-referenced, hyperlinked information accessible via a search engine.

Conclusions:

  • The CRDB serves as a vital gateway and repository for curcumin and curcuminoid research.
  • It is expected to significantly benefit researchers involved in molecular design and drug discovery.
  • This resource aims to overcome data accessibility challenges and accelerate scientific progress.