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Updated: Apr 6, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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A literature mining-based approach for identification of cellular pathways associated with chemoresistance in cancer

Jung Hun Oh, Joseph O Deasy

    Briefings in Bioinformatics
    |July 30, 2015
    PubMed

    Insights

    Chemoresistance, a major cancer treatment obstacle, involves complex mechanisms like cancer stem cells and drug efflux. This study provides a systems biology overview of chemoresistance mechanisms using pathway analysis and network algorithms.

    Area of Science:

    • Oncology
    • Systems Biology
    • Genetics

    Background:

    • Chemoresistance is a significant challenge in treating various human cancers.
    • Mechanisms include cancer stem cells, drug efflux, autophagy, and epithelial-mesenchymal transition.
    • Current understanding of chemoresistance biological mechanisms remains limited.

    Purpose of the Study:

    • To provide a systems biology-based overview of chemoresistance mechanisms.
    • To identify significant chemoresistance-related biological pathways.
    • To investigate the importance of chemoresistance markers in protein-protein interaction networks.

    Main Methods:

    • Literature survey of chemoresistance-related genes and pathways across multiple cancer types.
    • Analysis using a curated pathway database to identify significant pathways.
    • Application of a graph-based gene-ranking algorithm to protein-protein interaction networks.

    Main Results:

    • Identification of key biological pathways implicated in chemoresistance.
    • Evaluation of chemoresistance marker importance within biological networks.
    • A comprehensive systems biology perspective on chemoresistance mechanisms.

    Conclusions:

    • The study offers a systems biology framework for understanding chemoresistance.
    • Highlights the complexity of chemoresistance involving multiple genes and pathways.
    • Provides insights into potential therapeutic targets by analyzing molecular interactions.
    Keywords:
    cancerchemoresistancechemotherapygenepathwaysystems biology

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