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Antimicrobial resistance and virulence gene profiles in P. multocida strains isolated from cats

Thais Sebastiana Porfida Ferreira1, Maria Roberta Felizardo1, Debora Dirani Sena de Gobbi1

  • 1Laboratório de Epidemiologia Molecular e Resistencia a Antimicrobianos, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil.

Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology]
|July 30, 2015
PubMed

Insights

Pasteurella multocida is common in Brazilian cats

Area of Science:

  • Veterinary Microbiology
  • Zoonotic Diseases

Background:

  • Pasteurella multocida is a bacterium frequently found in the oral microbiota of cats.
  • It is associated with various feline diseases and can cause infections in humans, particularly after cat bites.
  • No previous studies have investigated P. multocida prevalence in Brazilian cats or associated human infections.

Purpose of the Study:

  • To determine the prevalence of Pasteurella multocida in healthy cats in São Paulo State, Brazil.
  • To characterize the isolated P. multocida strains, including capsular type, virulence genes, and antimicrobial resistance profiles.

Main Methods:

  • Oral swabs were collected from 191 healthy cats in São Paulo State.
  • Bacterial isolation and identification were performed using biochemical tests and PCR.
  • Characterization included capsular typing, detection of virulence genes (toxA, tbpA, pfhA), and antimicrobial susceptibility testing.

Main Results:

  • Pasteurella multocida was detected in 20 out of 191 (10.5%) healthy cats.
  • Of the 41 characterized strains, 75.6% were capsular type A.
  • No strains harbored toxA, tbpA, or pfhA genes. Resistance to sulfizoxazole and trimethoprim-sulfamethoxazole was common.

Conclusions:

  • Pasteurella multocida is present in the oral microbiota of healthy cats in Brazil.
  • The predominant capsular type is A, and specific virulence genes were absent in this study population.
  • Findings provide baseline data for understanding P. multocida epidemiology in Brazilian felines and potential zoonotic implications.
Keywords:
Pasteurela multocidacatisolationresistancevirulence genes

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