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Updated: Apr 6, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
ABCB1 polymorphism and susceptibility to acute lymphoblastic leukemia: a meta analysis
Haiyan Zhang1, Zhen Zhang1, Guang Li2
1Gynaecology Ward-1, Linyi City People's Hospital Linyi 276000, Shandong Province, China.
Background:
A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk.
Methods:
We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models.
Results:
We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations.
Conclusions:
These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians.
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