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Peroxisome proliferator-activated receptor γ Pro12Ala polymorphism decrease the risk of diabetic nephropathy in type
Jiarong Ding1, Chao Zhu2, Xiaobin Mei1
1Department of Nephrology, Changhai Hospital, Second Military Medical University Shanghai 200433, China.
Summary
The peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala polymorphism is linked to a reduced risk of type 2 diabetes mellitus (T2DN). This association was significant in Caucasians but not in Asians.
Area of Science:
- Genetics and Molecular Biology
- Metabolic Diseases
- Pharmacogenomics
Background:
- The link between peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala polymorphism and type 2 diabetes mellitus (T2DN) risk is debated.
- Previous studies have yielded inconsistent results regarding this association.
Purpose of the Study:
- To clarify the association between PPARγ Pro12Ala polymorphism and T2DN risk.
- To conduct a comprehensive meta-analysis of existing case-control studies.
Main Methods:
- Systematic literature search of PubMed and EMBASE databases.
- Meta-analysis of 20 case-control studies including 9357 participants.
- Calculation of odds ratios (ORs) and 95% confidence intervals (CIs) using an effect model based on heterogeneity testing.
Main Results:
- The PPARγ Pro12Ala polymorphism was significantly associated with a decreased risk of T2DN (OR = 0.74; 95% CI 0.59-0.94; P = 0.01).
- Subgroup analysis revealed a decreased T2DN risk in Caucasians with the PPARγ Pro12Ala polymorphism (OR = 0.63; 95% CI 0.46-0.88; P = 0.006).
- No significant association was found in Asians (OR = 0.87; 95% CI 0.62-1.22; P = 0.41).
Conclusions:
- The PPARγ Pro12Ala polymorphism may contribute to the risk of T2DN.
- The protective effect appears to be more pronounced in Caucasian populations.
