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Peroxisome proliferator-activated receptor γ Pro12Ala polymorphism decrease the risk of diabetic nephropathy in type

Jiarong Ding¹, Chao Zhu², Xiaobin Mei¹

¹Department of Nephrology, Changhai Hospital, Second Military Medical University Shanghai 200433, China.

International Journal of Clinical and Experimental Medicine

|July 30, 2015

Summary

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The peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala polymorphism is linked to a reduced risk of type 2 diabetes mellitus (T2DN). This association was significant in Caucasians but not in Asians.

Area of Science:

Genetics and Molecular Biology
Metabolic Diseases
Pharmacogenomics

Background:

The link between peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala polymorphism and type 2 diabetes mellitus (T2DN) risk is debated.
Previous studies have yielded inconsistent results regarding this association.

Purpose of the Study:

To clarify the association between PPARγ Pro12Ala polymorphism and T2DN risk.
To conduct a comprehensive meta-analysis of existing case-control studies.

Main Methods:

Systematic literature search of PubMed and EMBASE databases.
Meta-analysis of 20 case-control studies including 9357 participants.
Calculation of odds ratios (ORs) and 95% confidence intervals (CIs) using an effect model based on heterogeneity testing.

Keywords:

Diabetic nephropathy peroxisome proliferators-activated receptor γ polymorphism

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Main Results:

The PPARγ Pro12Ala polymorphism was significantly associated with a decreased risk of T2DN (OR = 0.74; 95% CI 0.59-0.94; P = 0.01).
Subgroup analysis revealed a decreased T2DN risk in Caucasians with the PPARγ Pro12Ala polymorphism (OR = 0.63; 95% CI 0.46-0.88; P = 0.006).
No significant association was found in Asians (OR = 0.87; 95% CI 0.62-1.22; P = 0.41).

Conclusions:

The PPARγ Pro12Ala polymorphism may contribute to the risk of T2DN.
The protective effect appears to be more pronounced in Caucasian populations.