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Updated: Apr 6, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Platelet-rich fibrin application in dentistry: a literature review
Eduardo Borie1, Daniel García Oliví2, Iara Augusta Orsi3
1Research Centre in Dental Sciences (CICO), Dental School, Universidad de La Frontera Temuco, Chile ; Dental Materials and Prosthodontics Department, Ribeirão Preto Dental School, University of São Paulo Ribeirão Preto, SP, Brazil.
Abstract:
The development of bioactive surgical additives to regulate the inflammation and increase the speed of healing process is one of the great challenges in clinical research. In this sense, platelet rich fibrin (PRF) appears as a natural and satisfactory alternative with favorable results and low risks. The following review attempts to summarize the relevant literature regarding the technique of using PRF, focusing on its preparation, advantages, and disadvantages of using it in clinical applications. PRF alone or in combination with other biomaterials seems to have several advantages and indications both for medicine and dentistry, due it is a minimally invasive technique with low risks and satisfactory clinical results.
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