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Updated: Apr 6, 2026
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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
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Endometrial Stromal Nodule: A Rarity and a Pathological Challenge.
Camilla Skovvang Borg1, Peter Humaidan2, Hanne Noer3
1Department of Obstetrics and Gynecology, Viborg Regional Hospital, 8800 Viborg, Denmark.
Case Reports in Obstetrics and Gynecology
|July 30, 2015
Summary
Endometrial stromal nodules are rare benign uterine tumors. Accurate histological diagnosis is crucial to distinguish them from malignant endometrial stromal sarcoma, impacting treatment and prognosis.
Area of Science:
- Gynecologic Pathology
- Reproductive Endocrinology
- Oncology
Background:
- Endometrial stromal tumors are rare gynecologic neoplasms.
- Endometrial stromal nodules (ESNs) represent the least common subtype.
- Distinguishing ESNs from malignant endometrial stromal sarcomas is critical due to differing prognoses.
Purpose of the Study:
- To report a rare case of endometrial stromal nodule with invasion.
- To highlight diagnostic challenges in differentiating benign ESNs from malignant stromal sarcomas.
- To underscore the importance of histological margin assessment.
Main Methods:
- Case report of a 38-year-old woman with a presumed uterine polyp.
- Initial transcervical polyp resection.
- Histopathological examination for definitive diagnosis and margin assessment.
Main Results:
- Histopathology revealed an endometrial stromal nodule with invasion (<3 mm).
- Unclear margins initially raised suspicion for malignant endometrial sarcoma.
- Definitive diagnosis confirmed a benign ESN despite minor invasion.
Conclusions:
- Endometrial stromal nodules, though benign, require careful histological evaluation.
- Accurate differentiation from malignant endometrial stromal sarcoma is essential for patient management.
- Hysterectomy remains the treatment of choice for both benign and malignant stromal tumors, with no reliable preoperative diagnostic tools.
