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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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Recurrent ischemic events and risk factors in patients with symptomatic intracranial artery stenosis

P-Q Wang1, J-J Liu, A-P Wang

  • 1Department of Neurology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei, China. zgb1969@126.com.

European Review for Medical and Pharmacological Sciences
|July 30, 2015
PubMed

Insights

Patients with symptomatic intracranial artery stenosis face a high stroke recurrence risk. Irregular statin use, diabetes, and severe stenosis significantly increase this risk.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Symptomatic intracranial artery stenosis is a significant cause of recurrent ischemic stroke.
  • Understanding risk factors for recurrence is crucial for effective patient management and secondary stroke prevention.

Purpose of the Study:

  • To evaluate the incidence of recurrent ischemic events in patients diagnosed with symptomatic intracranial artery stenosis.
  • To identify key risk factors associated with stroke recurrence in this patient cohort.

Main Methods:

  • A cohort of patients with acute cerebral infarction or transient ischemic attack (TIA) and intracranial arterial stenosis (confirmed by CTA) was followed.
  • Patients were categorized into recurrent and non-recurrent groups based on subsequent cerebrovascular events.
  • Statistical analyses, including logistic regression, were employed to determine factors correlating with recurrence.

Main Results:

  • Out of 142 patients, 16 (13.2%) experienced recurrent ischemic cerebrovascular events within one year.
  • Factors significantly associated with recurrence included irregular statin use (OR=3.719), diabetes (OR=1.842), and severe arterial stenosis (OR=1.503).
  • Recurrence was more common on the ipsilateral side of the initial vascular lesion.

Conclusions:

  • Symptomatic intracranial artery stenosis is linked to a substantial rate of stroke recurrence.
  • Irregular statin therapy, presence of diabetes mellitus, and degree of arterial stenosis are independent risk factors for recurrent stroke in these patients.
Abstract

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