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Fuchs' Uveitis Syndrome: No Longer a Syndrome?
Elke Olivia Kreps1, Thierry Derveaux1, Filip De Keyser2
1a University Hospital Ghent , Ophthalmology , Ghent , Belgium and.
Ocular Immunology and Inflammation
|July 30, 2015
Summary
Rubella virus (RV) is the primary cause of Fuchs
Area of Science:
- Ophthalmology
- Virology
- Immunology
Background:
- Fuchs' uveitis syndrome (FUS) is a chronic intraocular inflammatory condition.
- The role of rubella virus (RV) in FUS pathogenesis has been debated.
Purpose of the Study:
- To provide new insights into the etiopathogenesis of FUS.
- To comprehensively analyze recent laboratory and epidemiologic data regarding RV and FUS.
Main Methods:
- Literature search for laboratory data and etiopathogenesis studies.
- Analysis of aqueous humor samples for RV.
- Review of epidemiologic findings.
Main Results:
- Aqueous humor samples from FUS patients show specific and sensitive immunoreactivity to RV.
- RV genome identification confirms intraocular infection in some FUS patients.
- FUS eyes show CD8+ T cell predominance and elevated IFN-γ and IL-10 levels.
Conclusions:
- Rubella virus is identified as the leading cause of FUS.
- Cytokine profiles suggest a viral etiology and chronic inflammation.
- RV-associated FUS represents a common pathway of intraocular viral inoculation.
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