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High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and

Dardo Tomasi1, Ehsan Shokri-Kojori1, Nora D Volkow2

  • 1National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.

Cerebral Cortex (New York, N.Y. : 1991)
|July 31, 2015
PubMed
Summary

High-resolution MRI reveals precise brain hub locations, crucial for understanding neuropsychiatric disorders. Local Functional Connectivity Density (L: FCD) mapping offers a reliable biomarker for individual brain analysis.

Keywords:
FCDMagingglobal signal regressionmotionmultibandphysiologic noiseresting state

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Brain Connectivity

Background:

  • Brain regions with high connectivity have significant metabolic costs.
  • Disruptions in these highly connected regions are linked to neuropsychiatric disorders.
  • Previous group-level studies identified local functional connectivity density (L: FCD) hubs in occipito-parietal cortices, but lacked individual precision.

Purpose of the Study:

  • To investigate if higher spatiotemporal resolution MRI data can improve the precision of local functional connectivity density (L: FCD) hub localization.
  • To assess the gray matter (GM) specificity and sensitivity of high-resolution L: FCD patterns.
  • To evaluate the reliability and reproducibility of high-resolution L: FCD measures for potential clinical applications.

Main Methods:

  • Utilized high spatiotemporal resolution (2-mm isotropic; 0.72 s) MRI datasets from the Human Connectome Project (HCP).
  • Applied effective 0.01-0.08 Hz band-pass filtering to reduce spurious effects in white matter.
  • Calculated local functional connectivity density (L: FCD) and assessed its gray matter (GM) specificity, sensitivity, reliability (ICC(3,1)), and reproducibility.

Main Results:

  • Higher spatiotemporal resolution MRI significantly improved hub localization precision.
  • Revealed L: FCD patterns with >96% gray matter (GM) specificity and >75% sensitivity.
  • High-resolution L: FCD measures demonstrated high reliability (ICC(3,1) > 0.6) but lower reproducibility (>67%) compared to lower-resolution data.
  • GM sensitivity and specificity were robust to changes in model parameters and preprocessing.

Conclusions:

  • High spatiotemporal resolution MRI enables precise mapping of individual brain hubs using L: FCD.
  • L: FCD demonstrates high GM specificity and sensitivity, making it a promising biomarker.
  • The findings support the use of L: FCD as a potential biomarker for clinical applications in neuropsychiatric disorders.