Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

764
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
764
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

955
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
955
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

921
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
921

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uric acid to high density lipoprotein-cholesterol ratio as a potential biomarker of comorbidities in youth with obesity.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Circulating mRNA and miRNA signatures used as predictive markers of lifestyle modification outcomes in pediatric obesity management.

Hormone research in paediatrics·2026
Same author

Pharmacotherapeutic interventions for pediatric ulcerative colitis.

Expert opinion on pharmacotherapy·2026
Same author

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Practical approach to the diagnosis, management, and treatment of pediatric patients with bone fragility: an expert opinion.

Journal of endocrinological investigation·2026
Same author

Histological activity predicts relapse in pediatric ulcerative colitis despite mucosal healing: a multicenter study from the pediatric IBD Porto group of ESPGHAN.

Journal of Crohn's & colitis·2026

Related Experiment Video

Updated: Apr 6, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K

Renal Involvement in Inflammatory Bowel Diseases.

Domenico Corica1, Claudio Romano2

  • 1Department of Pediatrics, University of Messina, Messina, Italy.

Journal of Crohn'S & Colitis
|July 31, 2015
PubMed
Summary

Inflammatory bowel diseases (IBD) can cause kidney problems like stones and nephritis. This review examines the latest research on renal involvement in IBD patients.

Keywords:
Inflammatory bowel diseasesextraintestinal manifestationrenal disease

More Related Videos

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

69.4K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

596

Related Experiment Videos

Last Updated: Apr 6, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

69.4K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

596

Area of Science:

  • Nephrology
  • Gastroenterology
  • Immunology

Background:

  • Extraintestinal manifestations (EIMs) affect 6-46% of inflammatory bowel disease (IBD) patients.
  • The exact cause of EIMs is unknown, but theories involve immune responses and genetic factors.
  • While joints, skin, eyes, and liver are commonly affected, renal involvement is also a significant EIM.

Purpose of the Study:

  • To review and report key literature data on renal involvement in IBD patients.
  • To evaluate the prevalence and types of kidney disease associated with IBD.
  • To synthesize current knowledge on renal complications in Crohn's disease and ulcerative colitis.

Main Methods:

  • Bibliographical searches of the MEDLINE database from January 1998 to January 2015.
  • Keywords included IBD, Crohn's disease, ulcerative colitis, and various renal terms (kidney, renal, nephrolithiasis, nephritis, glomerulonephritis, etc.).
  • Searches also incorporated terms related to IBD medications (5-ASA, TNF-α inhibitors, cyclosporine, azathioprine) and pediatric populations.

Main Results:

  • Renal involvement in IBD includes nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis, and amyloidosis.
  • These renal issues can arise from the primary IBD pathophysiology, secondary complications, or shared autoimmune predispositions.
  • The review synthesizes data on these renal manifestations across different IBD types and treatments.

Conclusions:

  • Renal involvement is a recognized extraintestinal manifestation of inflammatory bowel diseases.
  • Understanding the spectrum of kidney diseases in IBD is crucial for patient management.
  • Further research is needed to elucidate the precise mechanisms and optimize treatment strategies for renal complications in IBD.