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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Apr 6, 2026

Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Merkel cell carcinoma: a review.

A E Verzì¹, S M Amin, J Guitart

¹Dermatology Clinic, University of Catania, Catania, Italy - cldermct@gmail.com.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|July 31, 2015

Summary

This summary is machine-generated.

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Diagnosis requires histology, and treatment involves surgery and radiotherapy, though new targeted therapies are being explored.

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Merkel Cell Polyomavirus Infection and Detection

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with increasing incidence and high mortality.
Etiology is multifactorial, involving UV radiation, immunosuppression, and Merkel cell polyomavirus.
Clinical presentation is often non-specific, typically appearing as a rapidly growing lesion on the head and neck.

Purpose of the Study:

To review and discuss current knowledge on Merkel cell carcinoma.
To highlight diagnostic and staging requirements.
To discuss current treatment modalities and future therapeutic perspectives.

Main Methods:

Review of current literature on Merkel cell carcinoma.
Discussion of clinical, histological, and immunohistochemical diagnostic criteria.
Analysis of staging procedures and treatment strategies.

Main Results:

Diagnosis relies on histological and immunohistochemical findings due to non-specific clinical presentation.
Staging requires evaluation for regional and distant metastases.
Multidisciplinary management, including aggressive surgery and adjuvant radiotherapy, is standard, but optimal therapy remains debated due to limited data.

Conclusions:

High-quality, multicentre, randomized studies are needed to establish optimal treatment protocols.
Targeted therapies offer potential future treatment avenues for MCC patients.
Current management focuses on multidisciplinary approaches combining surgery and radiotherapy.