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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

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Metabolic Syndrome and Cardiovascular Risk in Elderly Treated Hypertensive Patients

Sante D Pierdomenico1, Anna M Pierdomenico2, Roberta Di Tommaso3

  • 1Dipartimento di Medicina e Scienze dell'Invecchiamento, Università "Gabriele d'Annunzio", Chieti, Italy; Centro di Ricerca Clinica, Fondazione Università "Gabriele d'Annunzio", Chieti, Italy. pierdomenico@unich.it santedonato.pierdomenico@fastwebnet.it.

American Journal of Hypertension
|July 31, 2015
PubMed

Insights

Metabolic syndrome (MetS) increases cardiovascular risk in elderly hypertensive patients, but this association is not independent of blood pressure and glucose levels. Further analysis indicates organ damage also influences this risk.

Area of Science:

  • Cardiology
  • Geriatrics
  • Metabolic Diseases

Background:

  • The prognostic significance of metabolic syndrome (MetS) in elderly populations remains unclear.
  • Investigated the association between MetS and cardiovascular risk in elderly, treated hypertensive patients.

Purpose of the Study:

  • To determine if MetS independently predicts cardiovascular events (stroke, coronary events) in elderly treated hypertensive patients.
  • To explore the influence of MetS components and organ damage on cardiovascular risk.

Main Methods:

  • Evaluated cardiovascular outcomes in 1,191 elderly treated hypertensive patients (≥60 years).
  • MetS diagnosed using a modified definition (BMI instead of waist circumference).
  • Follow-up duration averaged 9.1 years; Cox regression analysis performed.

Main Results:

  • Univariate analysis showed MetS associated with higher composite cardiovascular endpoint risk (HR 1.322).
  • Blood pressure and impaired fasting glucose/diabetes were significant risk factors.
  • After adjusting for confounders and organ damage, MetS was not independently associated with increased cardiovascular risk (HR 1.090).

Conclusions:

  • MetS is linked to increased cardiovascular risk in elderly treated hypertensive patients.
  • This association is not independent of blood pressure, glucose levels, and existing organ damage.
Abstract

Keywords:
blood pressurecoronary eventselderlyhypertensionmetabolic syndromestroke.

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