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Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the

Rihab Bouchareb1, Ablajan Mahmut1, Mohamed Jalloul Nsaibia1

  • 1From Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery (R.B., A.M., M.J.N., M.-C.B., J.-L.L., M.-H.L., F.H., P.M.), Department of Medicine (A.D., P.P., B.J.A., A.M.), Department of Pathology (C.C., S.T., S.P.), and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; and Department of Chemistry and Biochemistry, University of Windsor, Ontario, Canada (C.A.S., R.R., M.L.K.).

Circulation
|July 31, 2015
PubMed
Summary

Lipoprotein(a) transports autotaxin (ATX) to the aortic valve, where ATX-lysophosphatidic acid promotes calcific aortic valve disease (CAVD) by driving inflammation and mineralization, suggesting a new therapeutic target.

Keywords:
ENPP2aortic stenosis, calcificaortic valve stenosisautotaxincalcific aortic valve diseaselipoprotein(a)lipoproteinslysophosphatidic acidlysophosphatidylcholine

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