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Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling

Thomas Ratajczak¹, Carmel Cluning¹, Bryan K Ward¹

¹Laboratory for Molecular Endocrinology, Harry Perkins Institute of Medical Research and the UWA Centre for Medical Research, The University of Western Australia, Nedlands WA 6009, Australia; ; Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands WA 6009, Australia.

The Clinical Biochemist. Reviews

|July 31, 2015

Summary

Steroid receptor-associated immunophilins (FKBP51, FKBP52, CyP40, PP5) regulate hormone function and gene activity. Their dysregulation links to diseases like cancer, diabetes, and depression, offering therapeutic targets.

Area of Science:

Molecular biology
Endocrinology
Immunology

Background:

Steroid receptor-associated immunophilins (FKBP51, FKBP52, CyP40, PP5) are crucial co-chaperones in complexes with heat shock protein 90 (Hsp90).
These immunophilins modulate steroid receptor activity, influencing hormone binding, cellular localization, and gene transcription in a tissue-specific manner.

Purpose of the Study:

To review the specific roles of FKBP51, FKBP52, CyP40, and PP5 in steroid receptor function.
To explore the link between aberrant immunophilin expression and various human diseases.
To highlight the potential for developing molecular therapies targeting immunophilin-controlled pathways.

Main Methods:

Literature review of studies on steroid receptor-associated immunophilins.
Analysis of their function as co-chaperones in Hsp90 complexes.
Examination of the connection between immunophilins and disease pathogenesis.

Main Results:

Immunophilins FKBP51, FKBP52, CyP40, and PP5 exhibit distinct functions in steroid receptor regulation.
Dysregulation of these immunophilins is implicated in diseases such as breast and prostate cancer, diabetes, metabolic disorders, infertility, and major depressive disorders.
Understanding their mechanisms provides avenues for therapeutic intervention.

Conclusions:

Steroid receptor-associated immunophilins are key regulators of steroid hormone action.
Their aberrant expression is a significant factor in the development of multiple human diseases.
Targeting these immunophilins offers promising therapeutic strategies for managing steroid-related disorders.

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