A purification system for ⁶⁴Cu produced by a biomedical cyclotron for antibody PET imaging

Ion exchange is a simple and efficient method for separating no-carrier-added ⁶⁴Cu from an irradiated Ni target. We developed a semi-automated two-round ⁶⁴Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of ⁶⁴Cu from the Ni target was achieved with high radiochemical purity. ⁶⁴Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.