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Updated: Apr 6, 2026
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Cholesterol confusion and statin controversy
Robert DuBroff1, Michel de Lorgeril1
1Robert DuBroff, Department of Medicine, Division of Cardiology, University of New Mexico School of Medicine, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131, United States.
World Journal of Cardiology
|July 31, 2015
Summary
Cholesterol-lowering statins
Area of Science:
- Cardiovascular medicine and nutrition science.
Background:
- The link between blood cholesterol and coronary heart disease (CHD) is debated.
- The efficacy of statins in reducing cardiac mortality and increasing lifespan is controversial.
Purpose of the Study:
- To review current data on statins and the Mediterranean diet.
- To evaluate the role of cholesterol reduction versus lifestyle in CHD prevention.
Main Methods:
- Literature review of studies on statins and the Mediterranean diet.
- Analysis of data concerning cholesterol levels, cardiac mortality, and longevity.
Main Results:
- The effectiveness of statins in preventing CHD and extending life is questionable.
- The Mediterranean diet is associated with prolonged life and reduced risk of major diseases, including CHD.
Conclusions:
- Preventing CHD solely by lowering cholesterol is likely unfounded.
- A healthy lifestyle, particularly the Mediterranean diet, offers proven benefits for CHD prevention.
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