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Cholesterol confusion and statin controversy

Robert DuBroff1, Michel de Lorgeril1

  • 1Robert DuBroff, Department of Medicine, Division of Cardiology, University of New Mexico School of Medicine, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131, United States.

World Journal of Cardiology
|July 31, 2015
PubMed

Insights

Cholesterol-lowering statins

Area of Science:

  • Cardiovascular medicine and nutrition science.

Background:

  • The link between blood cholesterol and coronary heart disease (CHD) is debated.
  • The efficacy of statins in reducing cardiac mortality and increasing lifespan is controversial.

Purpose of the Study:

  • To review current data on statins and the Mediterranean diet.
  • To evaluate the role of cholesterol reduction versus lifestyle in CHD prevention.

Main Methods:

  • Literature review of studies on statins and the Mediterranean diet.
  • Analysis of data concerning cholesterol levels, cardiac mortality, and longevity.

Main Results:

  • The effectiveness of statins in preventing CHD and extending life is questionable.
  • The Mediterranean diet is associated with prolonged life and reduced risk of major diseases, including CHD.

Conclusions:

  • Preventing CHD solely by lowering cholesterol is likely unfounded.
  • A healthy lifestyle, particularly the Mediterranean diet, offers proven benefits for CHD prevention.

Keywords:
Cardiovascular diseaseCholesterolCoronary heart diseaseMediterranean dietMortalityStatins

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