Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

2.6K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
2.6K
Molecular Models02:00

Molecular Models

45.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
45.6K
Biostatistics: Overview01:20

Biostatistics: Overview

1.1K
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
1.1K
Synthetic Biology02:55

Synthetic Biology

5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.8K
Bioequivalence: Overview01:16

Bioequivalence: Overview

2.2K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
2.2K
Induced-fit Model01:13

Induced-fit Model

92.0K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
92.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and efficacy of encorafenib-cetuximab combination in <i>BRAF</i> <sup><i>V600E</i></sup> -mutated metastatic colorectal cancer: real-world evidence from the CONFIDENCE Spanish multicenter study.

ESMO real world data and digital oncology·2026
Same author

Automatic milking unit preference of Holstein, Jersey, and Holstein-Jersey crossbred cows in a batch milking system.

Journal of dairy science·2025
Same author

Scaling Law for Epithelial Tissue Rheology.

Physical review letters·2025
Same author

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Tribology letters·2025
Same author

Milking behavior and performance of primiparous and multiparous Holstein, Jersey, and Holstein × Jersey crossbred cows in a batch milking system with automatic milking units.

Journal of dairy science·2025
Same author

Perivascular epithelioid cell tumors (PEComas) of gynecological tract: preoperative diagnostic imaging challenge.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same journal

Integrated Population Pharmacokinetic Analysis of Intravitreal Aflibercept Drug Products.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Development and Use of a Population Pharmacokinetic Model for Characterizing the Pharmacokinetics of Vonoprazan in Pediatric Patients.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

A Narrative Review of Artificial Intelligence for Drug Repurposing: Lessons From COVID-19 and Oncology (2020-2025).

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Butorphanol Pharmacokinetics Across Species: Meta-Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Automated Pharmacometric Model Development by Leveraging Low-Dimensional Neural ODEs and LASSO Regression.

CPT: pharmacometrics & systems pharmacology·2026
See all related articles

Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.5K

BioModels: Content, Features, Functionality, and Use.

N Juty1, R Ali1, M Glont1

  • 1European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus Hinxton, Cambridge, UK.

CPT: Pharmacometrics & Systems Pharmacology
|July 31, 2015
PubMed
Summary
This summary is machine-generated.

BioModels is a comprehensive repository for biological mathematical models, offering over 1,200 curated literature models and 140,000 automatically generated pathway models for enhanced research reproducibility and interoperability.

More Related Videos

Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

3.1K
Modeling an Enzyme Active Site using Molecular Visualization Freeware
14:37

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

11.9K

Related Experiment Videos

Last Updated: Apr 6, 2026

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.5K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

3.1K
Modeling an Enzyme Active Site using Molecular Visualization Freeware
14:37

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

11.9K

Area of Science:

  • Systems Biology
  • Computational Biology
  • Bioinformatics

Background:

  • Mathematical models are essential for understanding complex biological systems.
  • Access to curated and diverse biological models is crucial for research.
  • Interoperability and reproducibility are key challenges in computational biology.

Purpose of the Study:

  • To present the BioModels database, a key resource for biological modeling.
  • To detail the content, features, and functionality of the BioModels repository.
  • To provide guidance on the usage of BioModels for researchers.

Main Methods:

  • The BioModels database aggregates manually curated and automatically generated mathematical models.
  • Models cover various biological scales and are linked to external resources.
  • A tutorial format is used to explain the database's structure and access methods.

Main Results:

  • BioModels hosts over 1,200 literature-based models and over 140,000 pathway-derived models.
  • Extensive cross-linking with external databases enhances model interoperability.
  • Manual curation ensures the reproducibility of simulation results for a significant portion of models.

Conclusions:

  • BioModels serves as a vital, centralized resource for biological mathematical models.
  • The database facilitates research by providing accessible, interoperable, and reproducible models.
  • This tutorial empowers users to effectively leverage BioModels for their research needs.