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[Fibrinogen, a cardiovascular risk factor]
Insights
High fibrinogen levels significantly increase cardiovascular disease risk, comparable to smoking or high cholesterol. Monitoring fibrinogen is crucial for assessing cardiovascular risk, especially in men.
Area of Science:
- Biochemistry
- Cardiology
- Hematology
Context:
- Cardiovascular disease (CVD) poses a significant global health burden.
- Established risk factors for CVD include smoking, hyperlipidemia, and hypertension.
- The role of plasma fibrinogen levels as an independent CVD risk factor requires further elucidation.
Purpose:
- To investigate the association between plasma fibrinogen levels and cardiovascular disease.
- To compare the prognostic significance of fibrinogen with other known CVD risk factors.
- To determine the impact of fibrinogen levels on cardiovascular risk, particularly in different demographic groups.
Summary:
- Fibrinogen levels were assessed in 45 cardiovascular disease patients and 45 healthy controls.
- A significantly higher prevalence of elevated fibrinogen was observed in patients with cardiovascular disease (55%) compared to healthy controls (6.6%).
- Elevated fibrinogen demonstrated a consistent impact on cardiovascular disease risk across all age groups in men.
Impact:
- Fibrinogen elevation may indicate underlying hypercoagulability, hyperviscosity, and increased platelet aggregation, contributing to CVD.
- Plasma fibrinogen level measurement is proposed as an important tool in cardiovascular risk assessment.
- Findings suggest fibrinogen is a valuable independent predictor of cardiovascular events.
Abstract:
Fibrinogen level is an independent predisposing factor for coronary heart disease and has a prognostic significance comparable with that of cigarette smoking, serum cholesterol level and hypertension. In our study fibrinogen levels were measured in 45 patients with cardiovascular disease of which 25 (55%) had a high fibrinogen level and in 45 persons healty, of which only 3 (6.6%) increased fibrinogen. The impact of fibrinogen level on the risk of cardiovascular disease was more consistent in men of all ages considered. The authors note that the independent contribution of fibrinogen to the cardiovascular risk may reflect hypercoagulability, hyperviscosity and increased platelet aggregation. Therefore they consider, the dosing of fibrinogen level important in the research of cardiovascular risk factors.